Yes, you are changing the unsprung weight and total sidewall thickness, so the performance and handling will be affected. Better or worse is a matter of opinion.
'82 CJ-7 w/5.9L and stuff (sold)
'96 ZJ Laredo 4x4 w/lift, gears, locker and stuff (sold)
'06 WK v6 Laredo 4x4 w/...foglights (sold)
'05 Subaru Legacy GT w/lots of track stuff (current)
'14 WK2.5 v6 Overland 4x4 (current)