Yes the Focal ISS 690 components will bolt right into the OEM speaker locations.
The tweeters fit in the OEM location but they are tight and you may have to "open up" the tweeter mounting spots with some sandpaper or very slight trimming
with an razor knife. I used a 1 1/2" sanding drum mounted into a low speed cordless drill to open up the tweeter holes. Others have used a dremel rotary tool to open up the mounting holes.
Do this very slow and carefully, you don't need to remove much material at all!
If you have OEM alpine components already just use the existing speaker wires as they already send the proper frequencies to the Focal components.
Check out this thread for detailed install instructions;
Focals ISS 690, ISC 165 & Polk db351 install tutorial with pics